N400 and Automatic Semantic Processing Abnormalities in Patients With Schizophrenia
نویسندگان
چکیده
منابع مشابه
N400 and automatic semantic processing abnormalities in patients with schizophrenia.
BACKGROUND One factor hypothesized to underlie thinking disturbance in patients with schizophrenia is abnormal or disinhibited automatic spreading activation of semantic networks, which can be assessed using the N400 event-related potential. N400 is a negative-going component elicited at about 400 milliseconds following semantic stimuli that are not primed by the preceding context. Semantic pri...
متن کاملAutomatic semantic priming abnormalities in schizophrenia.
Abnormal activation of semantic networks characterizes schizophrenia and can be studied using the N400 event-related potential (ERP). N400 is elicited by words that are not primed by the preceding context and provides a direct measure of the neural mechanisms underlying semantic priming. Semantic priming refers to facilitated semantic processing gained through pre-exposure to semantic context, ...
متن کاملSemantic Processing Disturbance in Patients with Schizophrenia: A Meta-Analysis of the N400 Component
BACKGROUND Theoretically semantic processing can be separated into early automatic semantic activation and late contextualization. Semantic processing deficits have been suggested in patients with schizophrenia, however it is not clear which stage of semantic processing is impaired. We attempted to clarify this issue by conducting a meta-analysis of the N400 component. METHODS Twenty-one stud...
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To examine the neurophysiological and cognitive characteristics of thought disturbance in schizophrenic patients, we examined the amplitude, latency, and topography of a specific event-related brain potential (ERP), the N400, which is elicited by semantically incongruent words and phrases. Twelve chronic schizophrenic patients and twelve age-matched control subjects read sentences presented vis...
متن کاملN400 to lexical ambiguity and semantic incongruity in schizophrenia.
Our previous work showed a semantic bias in interpreting ambiguous words in schizophrenia, with disproportionate misinterpretation of subordinate meanings (toast at a wedding). We proposed pre-selection in schizophrenia of dominant-meaning networks at points of lexical ambiguity, thereby misleading thought. This selection bias may be due to semantic memory hyper-priming causing strong associate...
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ژورنال
عنوان ژورنال: Archives of General Psychiatry
سال: 2002
ISSN: 0003-990X
DOI: 10.1001/archpsyc.59.7.641